Referring the studies listed above, lncRNAs regulating the proliferation of HCC cells in various of ways,which may concluding control the stability of p53 to make it more easy to be denatured and interact with HBx to downregulate the expression of PTEN, or co-recruitment both HBx and DLEU2 on the HBV cccDNA to replaces EZH2 on viral chromatin and promotes viral transcription and replication which may enhance the proliferation of HCC cells. The gene discussed is DLEU2; the disease is hepatocellular carcinoma.