As high expression of human epidermal growth factor receptor 2 (HER2) in PAC is associated with poor prognosis, the study showed the activity of HER2-specific CAR-T cell (HER2.CART) to improve by the addition of an oncolytic virus (CAdTrio) which produces IL-12, immune checkpoint inhibition anti-PD-L1, and safety switch HSVtk. Here, ERBB2 is linked to gonorrhea.