In HSC-humanized NSG mice engrafted with human B cell lymphoma, an anti-tumoral effect of the T cell bispecific antibody CD20-TCB was observed, mediated by the fast formation of stable T cell-tumor cell synapses inducing tumor cytotoxicity and cytokine synthesis, and by T cell recruitment to the tumor as well as resident T cell proliferation (79). This evidence concerns the gene PKM and neoplasm.