Given the association between USP7 and a few signaling pathways in tumor progression [such as NF-κB pathway (105), Wnt/β-Catenin pathway (106), Hippo pathway (107), and NOTCH pathway (108)], more related mechanistic investigations on USP7 regulation are needed to develop new targeting strategies in cancer therapy. The gene discussed is NFKB1; the disease is neoplasm.