In chronic myelogenous leukemia (CML), USP7 is required for stabilization of BCR-ABL and activation of BCR-ABL signaling (83).Inhibiting USP7 was shown to cause BCR-ABL destabilization and to trigger apoptotic signaling pathways (83). The gene discussed is USP7; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.