CMML associated with mastocytosis, CMML and blastic plasmacytoid dendritic cell neoplasm, CMML associated with eosinophilia (77–79), t-CMML (85), pre CMML syndromes (oligo-monocytic CMML) (86, 87), CMML with JAK-2 mutation, CMML with rearranged PDGFRA, PDGFRB, FGFR1, PCM1-JAK2, other MPN (MF, PV.) with monocytosis (“MPN with CMML-like phenotype”) (88). This evidence concerns the gene PCM1 and Down syndrome.