In NSCLC patients, NEDD4L rs11660748 A>G and rs73440898 A>G had adjusted hazard ratios (HRs) of 1.31 and 1.27, respectively, for overall survival, which means that the mutations at these two sites might impair the prognosis of patients. The gene discussed is NEDD4L; the disease is non-small cell lung carcinoma.