FOXO1 and cancer: In addition, pseudokinase Tribble 3 (TRIB3) interacted with Akt and repressed NEDD4L-mediated ubiquitination of Forkhead box O1 (FOXO1) and then promoted the expression of Sry-related high-mobility box 2 (SOX2), a transcription factor of cancer stem cells, to exacerbate the development of breast cancer stem cells (77).