The release of three primary damage associated molecular patterns (DAMPs) being membranous translocation of CALR, release of ATP and HMBG1, enables ICD to engage dendritic cell (DC) maturation which prompts DC migration to tumor draining lymph nodes, antigen presentation, and expression of required co-stimulatory molecules for T cell activation (57, 60, 180). This evidence concerns the gene CALR and neoplasm.