We further explored the combination of the dichotomized tumor location status and PET/CT-Rad Model for IDH mutation status prediction, and results indicated the predictive efficacy slightly enhanced in terms of AUC and accuracy (from 0.912 to 0.917 and 86.2% to 87.9%, respectively), although the enhancement was statistically insignificant. The gene discussed is IDH1; the disease is neoplasm.