When located on chromosome 9p24.1 After amplification and translocation of CD274, the gene encoding PD-L1, in some tumors (primary mediastinal large B lymphocytoma, non-small cell lung cancer, squamous cell carcinoma and EBV-positive gastric cancer) there may be an increase in PD-L1 expression levels (38, 39). Here, CD274 is linked to squamous cell carcinoma.