By translating the most significantly expressed gene matrix into clinical datasets of oral cancer tissues, we showed that the summed expression of FN1, TGFB2, TGFBR2, and TGFBI, dubbed the CAF index, is a poor indicator of overall survival for oral cancer (n=40) and the PANCAN (n=9,356) cohorts (11). Here, TGFBR2 is linked to lip and oral cavity carcinoma.