The results indicated that the expression of tumor cell-derived VEGFA, IGFBP3, EFNA1, EFNB1, IGF2, PDGFA and stroma-derived Angpt2, Cdh5, Esam, Esm1, Icam2, and Tie1 was statistically correlated with that of Pecam1 (Figure 2A) and elevated in p-EMT TW2.6 tumors (Figure 2B). Here, ESAM is linked to neoplasm.