First, genes identified in the xenograft experiments were validated for their primary origins of expression by cell typing of the scRNA-seq database, including myofibroblasts (IL6, ACTA2, MYL9, TAGLN), myCAFs (TGFBI, TGFB2, FN1, THY1, COL12A1, FAP, HAS1, HAS2), iCAFs (FAP, CXCL12, GSN), endothelial cells (PECAM1, TGFBR2, HYAL1, HYAL2), mast cells (HYAL3), T cells (HYAL4) and tumor cells (HAS3) (Figures 4C, 5A). The gene discussed is HYAL2; the disease is neoplasm.