TGFBI is a secretory extracellular matrix protein that mediates binding to other matrices, including fibronectin, laminin, and collagen of types I, II, IV, etc. As a direct target of TGFβ, TGFBI plays a tumor-suppressive role in early precancerous lesions but acts to promote tumor progression in later stages. This evidence concerns the gene TGFBI and neoplasm.