By translating the most significantly expressed gene matrix into clinical datasets of oral cancer tissues, we showed that the summed expression of FN1, TGFB2, TGFBR2, and TGFBI, dubbed the CAF index, is a poor indicator of overall survival for oral cancer (n=40) and the PANCAN (n=9,356) cohorts (11). The gene discussed is FN1; the disease is lip and oral cavity carcinoma.