CD274 and neoplasm: To the best of our knowledge, there are no consensus cutoff values of PD-L1 and CD8+ TILs, even though the Food and Drug Administration (FDA) approved the cutoff of 50% tumor proportion score for first-line therapy with pembrolizumab and 1% tumor proportion score for second-line therapy with pembrolizumab/atezolizumab/bevacizumab (39).