KLK4 and posterior cortical atrophy: Other proposed PSA-related biomarkers, the four-kallikrein panel (4K) and the Prostate Health Index (PHI), evaluated on 531 men with PSA 3–15 ng/ml undergoing first-time prostate biopsy, thus on a quite similar context, showed AUCs of 0.69 and 0.70, respectively, when predicting any-grade PCa (29).