BRAF and neoplasm: have demonstrated an interesting relation between mutations and pathological features: a) IDH1 alone or IDH/IDH2 is associated with bilobar invasion of the tumor; b) KRAS alone with positive margins (R1) and direct invasion of surrounding organs and KRAS, NRAS, or BRAF with R1; and c) NRAS with intrahepatic metastasis (47).