During this process, laminin protein in the extracellular matrix (ECM) could be cleaved by NE and matrix metalloproteinase 9 (MMP9) coating on NETs; the cleaved subset of laminin could interact with integrin α3β1 of tumor cells, which then activates the focal adhesion kinase (FAK), MAP kinase ERK kinase (MEK), and myosin light chain 2 (MLC2) to finally awaken the dormant cancer cells (105). Here, MMP9 is linked to neoplasm.