CCR8 and breast cancer: Especially in BC, CCR5, CCR8, CCR10, CX3CR1, CXCR3, and CXCR6 are stably and differentially expressed by tumor-resident Treg cells at the mRNA and protein levels (46, 47). While CCR4 was highly expressed by both tumor and peripheral blood Treg cells, CCR7 and CCR9 were downregulated in the Treg of TME.