<h4>Objective</h4>The aim of the study was to present a case of penile squamous cell carcinoma and immunohistochemical identification and evaluation of E-cadherin and β-catenin expression.<h4>Methods</h4>We are presenting a 70-year old man with a variant of penile squamous cell carcinoma with mixed warty and basaloid features. Here, CDH1 is linked to squamous cell carcinoma of penis.