VEGFA and neoplasm: In addition, anti-EGFR-based chemotherapy showed a higher early tumor shrinkage (ETS) rate (68.2% vs. 49.1% in FIRE-3; 64% vs. 45% in PEAK) and deeper DpR (48.9% vs. 32.3%, p<0.0001 in FIRE-3; 65% vs. 46%, p=0.0007 in PEAK) compared with anti-VEGF-based chemotherapy (35).