HK2 and hepatocellular carcinoma: Exosomal circCCT3 derived from CAFs can stimulate the activity of glucose metabolism-related gene HK2 and further affect the glucose metabolism of HCC cells (151), which is blocked by coptisine, the main component of Chelidonium majus L., Corydalis uanhusuo W. T. Wang, and Coptis japonica Makino (152).