A recent study found that co-culture with CAFs maintains sorafenib resistance in HCC cells through B-cell-activating factor (BAFF)/NF-κB-dependent pathway (42); otherwise, overexpressed immunosuppressive cell differentiation (CD)-73 in cancer cells induced by CAFs can facilitate the resistance of sorafenib and cisplatin in HCC patients (60, 61). This evidence concerns the gene TNFSF13B and hepatocellular carcinoma.