In order to identify the key upregulated genes in chemoresistance AML, we performed a Venn diagram analysis of the upregulated DEGs among R/R-AML, S-AML, R-AML, and primary/de novo AML patients, and the result revealed a total of 12 overlapping genes: CENPE, ASPM, CENPF, DLGAP5, KIF15, HMMR, BUB1B, KIF11, CEP55, NCAPG2, CCNB2, and CDCA8 (Figure 1H). The gene discussed is CDCA8; the disease is acute myeloid leukemia.