SMC4 and central nervous system cancer: There are three major histological subtypes of glioma (astrocytoma, oligoastrocytoma and oligodendroglioma) and SMC4 overexpression correlated with the reduced OS in astrocytoma and oligodendroglioma (Figure 3D, the top panel) and correlated with reduced PFI in astrocytoma and oligo-astrocytoma (Figure 3D, the bottom panel).