We identified SMC4, FANCB, WEE1, neoplasm histologic grade and new tumor event after initial treatment as independent markers for the OS, and identified TOP2A, WEE1, mold/dust allergy, neoplasm histologic grade, new tumor event after initial treatment and preoperative corticosteroids as independent markers for PFI (Figure 2A). This evidence concerns the gene TOP2A and neoplasm.