TOP2A and neoplasm: Based on the result of multivariate Cox regression model, we calculated the risk score for OS (OSrisk= 0.882 * SMC4 - 0.759 * FANCB + 0.678 * WEE1 + 1.316 * neoplasm histologic grade + 0.828 * new tumor event after initial treatment) and PFI (PFIrisk = -0.132 * TOP2A + 0.533 * WEE1 + 1.667 * mold or dust allergy + 0.795 * neoplasm histologic grade + 2.045 * new tumor event after initial treatment + 0.553 * preoperative corticosteroids), respectively.