IGF2 and cancer: Insulin-like growth factor 2 (IGF2) mRNA-binding protein 1 (IGF2BP1) belongs to the IGF2BP RNA-binding family proteins (21), required for stabilization and translation of several mRNAs in human cancer (22, 23), including Gli1 (glioma-associated oncogene homolog 1), Myc, IGF2 and SOX9 (24).