Another similar hub gene Serpin family H member 1 (SERPINH1), also known as HSP47, was proved to promote GBM stem-like cell survival by modulating tumor microenvironment through TGF-β pathway (34) and enhance glioma angiogenesis through HIF1α-VEGFR2 signaling (35). The gene discussed is HIF1A; the disease is glioma.