In addition, C–X–C motif chemokine receptor 4 (CXCR4), C–X–C motif ligand 3 (CXCL3), and matrix metallopeptidase 7 (MMP7), also considered as positively correlated genes, were reported as oncogenic genes and facilitate growth, invasion, migration, and chemoresistance in gliomas (27–29). Here, CXCL3 is linked to central nervous system cancer.