Moreover, we analyzed the Repository of Molecular Brain Neoplasia Data (REMBRANDT) (29) and the Chinese Glioma Genome Atlas (CGGA) (30) (http://www.cgga.org.cn) databases, and we found that WDR12 was significantly and positively correlated with genes encoding stem cell markers, including Sox2, Olig2, Nes, Sox11, Notch1, NFIB, ASCL1 and CHD7, in both glioma databases (Figure 1E and Supplementary Figure 1B). The gene discussed is NES; the disease is central nervous system cancer.