CTLA4 and non-small cell lung carcinoma: The phase 1 GEFTREM trial (NCT02040064) evaluated the safety of dose-escalation of the CTLA-4 inhibitor tremelimumab (3 mg/kg, 6 mg/kg, and 10 mg/kg) in combination with gefitinib in previously treated EGFRm NSCLC patients (73).