EGFR and non-small cell lung carcinoma: Osimertinib was initially approved in 2015 for second-line treatment of EGFR T790M-mutant NSCLC after progression on first-line EGFR-TKIs; however, this approval was expanded to first-line use after the landmark FLAURA study demonstrated significantly increased PFS with osimertinib versus standard EGFR-TKIs of 18.9 versus 10.2 months (HR for PFS 0.46, 95% CI 0.37-0.57, p<0.001) and improved OS of 38.6 versus 31.8 months (HR for death 0.80, 95% CI 0.64-1.00, p = 0.046) (22–24).