SQSTM1 and neoplasm: It should be noted, however, that although tumor tissues of mice treated with the combination UAMC-2526/gemcitabine showed a significant decrease of tumor growth as compared to the individual treatments (or the vehicle-treated group), we could not correlate the decreased tumor growth with autophagy inhibition as typical features of autophagy inhibition such as a decrease in LC3-II, accumulation of the selective autophagy receptor p62 or an impaired formation of autophagic vesicles could not be demonstrated.