showed that CgA level (high vs low at a cut off value of 420 ng/ml) was an independent predictive factor for OS in small pancreatic NET (tumor ≤ 2 cm) patients in multivariate analysis after adjusting for tumor size, grade, nodal status, and academic status of the facility (HR=7.9, 95% CI, 2.34-26.69, P=0.001) (21). The gene discussed is CGA; the disease is pancreatic neuroendocrine tumor.