In our study, we observed that the patients with a 40% or greater increase of CgA during treatment or surveillance had a higher risk of developing tumor progression than those with less than a 40% increase of CgA during follow-up with an OR of 5.04 (95% CI, 1.31-19.4, P=0.019) by multivariate logistic regression. The gene discussed is CGA; the disease is neoplasm.