From these later nine genes, TIGD1 was the only gene for which synonymous genetic variants were also detected (in addition to non-synonymous variants) in 5/32 tumors (16%). Out of all recurrent non-synonymous genetic variants identified in our patients, only a subset of them involving the ARID1B, NF2, POLR2A, PTEN, SMARCA4, and SMO genes had been previously reported in sporadic meningiomas (Supplementary Table 2). This evidence concerns the gene TIGD1 and meningioma.