POLR2A and neoplasm: Other genes that recurrently carried non-synonymous genetic variants at lower frequencies included the PNMA6A (7/32 tumors, 22%), TIGD1 (5/32, 16%), SMO (4/32, 13%), PTEN (4/32, 13%), CREG2 (3/32, 9%), EEF1A1 (2/32, 6%), and POLR2A (2/32, 6%) genes; in turn, the ARID1B and FAIM3 genes were found to be mutated in a single tumor each (1/32, 3%) (Table 1).