SMO and meningioma: Likewise, mutations involving the AKT1 (v-Akt murine thymoma viral oncogene homolog-1), KLF4 (Kruppel-like factor 4), PIK3CA (phosphatidylinositol 3-kinase), SMARCA4 (actin-dependent regulator of chromatin, subfamily A, member 4), and SMO (Smoothened) genes have also been recurrently reported at variable frequencies in sporadic meningioma (12, 14, 15), together with altered ARID1B, BAP1, PTEN, TP53, and TRAF7 gene profiles, as revealed via gene panel (15) and a limited number of whole exome sequencing (WES) plus whole genome sequencing (WGS) (4, 11, 12, 15) studies.