NF2 and neoplasm: Most interestingly, when we simultaneously considered the tumor cytogenetic patterns and the NF2 mutation profile, four distinct genetic profiles were identified, which could be grouped into two good-prognosis genetic profiles (diploid karyotype and isolated monosomy 22/22q─ associated with NF2 mutation), and two poor-prognosis genetic patterns (isolated monosomy 22/22q─ in the absence of NF2 mutation and complex karyotypes) with significantly different RFS rates.