In turn, non-synonymous variants of the NF2, POLR2A, and PTEN genes were identified in tumor samples from 2/3, 1/3, and 1/3 patients investigated, respectively, while they were systematically absent in blood DNA (Supplementary Table 3), supporting the specific acquisition of these genetic variants in the tumor cells of these patients. This evidence concerns the gene POLR2A and neoplasm.