Another four genes (PNMA6A, TIGD1, PTEN, and SMO) were found to be altered in >10% of all WHO grade 1 meningiomas investigated, while the remaining CREG2, EEF1A1, and POLR2A genes were recurrently altered in a minority (<10%) of cases. The gene discussed is PNMA6A; the disease is meningioma.