Among patients’ information and their tumor characteristics, four factors including the number of lymph node involvement, the expression levels of ER and PR, tumor diameter, and tumor tissue classification had a significant effect on the efficacy of TAM (Node-Negative vs. Node < 4, p = 5.3e−07; Node < 4 vs. Node ≥ 4, p = 0.003; Node-Negative vs. Node ≥ 4, p = 7.2e−15; ER < 50% vs. ER ≥ 50%, p = 1.3e−12; PR < 50% vs. PR ≥ 50%, p = 2.6e−08; tumor Size < 2cm vs. tumor Size ≥ 2cm, p = 0.013; tumor Grade < 2 vs. Grade ≥ 2, p = 2.2e−16; Figure S6). Here, ESR1 is linked to neoplasm.