BRD2 and neoplasm: After incorporating the residual tumor size, N classification after NAT, pCR and ctDNA after NAT, multivariate analysis showed that an N3 classification and ctDNA positivity after NAT were independent risk factors that predicted tumor recurrence (N3, hazard ratio (HR) 3.352, 95% CI 1.267 – 8.870, p = 0.015; ctDNA, HR 4.135, 95% CI 2.014 – 8.491, p < 0.0001).