Moreover, due to the extremely high frequency of CSF3R mutations in CNL (39), these mutations constitute a criterion for the diagnosis of CNL and, along with other morphological and clinical features, help distinguish CNL from aCML In fact, the identification of a CSF3R mutation in a patient with hepatosplenomegaly, hyperleukocytosis with prominence of neutrophils, low percentage of peripheral blood immature granulocytes and myeloblasts, along with minimal or absent dysgranulopoiesis in the bone marrow strongly favors the diagnosis of CNL over aCML. Here, CSF3R is linked to Hepatosplenomegaly.