TIMP3 and neoplasm: In the final week of tumor progression in the mice with the expected late-stage development of ascites, gene expression was overall higher in the ascites-derived samples, with significant increases in COL5A1 (p = 0.0056, 43.1-fold change), AEBP1 (p = 0.0093, 8.54-fold change), TIMP3 (p = 0.0004, 58.4-fold change), and ACTB (p = 0.0004, 3.98-fold change) (Figure 6C).