During week 3 of tumor development, non-quantifiable increases in gene expression of tumor-bearing sEVs were observed in COL5A1 and SNAI1 (absence vs. presence of target gene Cq values), and significant quantifiable increases in gene expression were observed in LOX (p = 0.0318, 4.37-fold change) and ACTB (p = 0.0006, 16.3-fold change) (Figure 3F). The gene discussed is COL5A1; the disease is neoplasm.