During early tumor progression (weeks 1 and 2 of development), there was no significant difference in plasma-derived and ascites-derived sEV gene expression, however, differences in expression of certain genes (AEBP1, COL11A1, and LOX) could not be quantified at week 1 due to undetermined Cq values in the plasma samples (Figures 6A, B). The gene discussed is COL11A1; the disease is neoplasm.