Induction of EMTCancer metastasis (bone)Inhibition of anti-tumor responsesReduce the expression of MHC-IAngiogenesis via regulating IL-8 expressionFormation of premetastatic nicheCTC attachment to endothelialStimulation of extravasationTME remodelingAlteration of the bone tissue. This evidence concerns the gene CXCL8 and neoplasm.