In this context, a study on human PC (LNCaP) cell line showed that tumor necrosis factor-α (TNF-α) and IL-17 could induce protein expression of programmed cell death protein ligand 1 (PDL-1) on the surface of tumor cells as an inhibitory molecule that is involved in CTLs suppression through activation of NF-κB signaling pathway (61). The gene discussed is TNF; the disease is neoplasm.