Evaluation of IL-12 biostructure showed that it is composed of two different subunits termed p40 and p35, and it has been reported that p40 is involved in the facilitation process of tumor cell escape from immune responses and also cell death as well as the arrest of IL-12Rβ1 but not IL-12Rβ2 (93). The gene discussed is IL12RB1; the disease is neoplasm.