Moreover, in metastatic PC, numerous circulating tumor cells (CTCs) can express mesenchymal (vimentin, N-cadherin and O-cadherin), stem cells (CD133), and epithelial cell (E-cadherin, epithelial cell adhesion molecule (EpCAM), and cytokeratins) markers (37). The gene discussed is EPCAM; the disease is pachyonychia congenita.