EZH2 and non-small cell lung carcinoma: LncRNA UCA1 was up-regulated in non-small-cell lung cancer tissues and gefitinib resistant cells, indicating that lncRNA UCA1 played a special role in gefitinib resistance, and lncRNA UCA1 knockout can increase the sensitivity to gefitinib by inhibiting cell proliferative capacities by interacting with EZH2 to epigenetically reduce CDKN1A expression (21).