LncRNA UCA1 was up-regulated in non-small-cell lung cancer tissues and gefitinib resistant cells, indicating that lncRNA UCA1 played a special role in gefitinib resistance, and lncRNA UCA1 knockout can increase the sensitivity to gefitinib by inhibiting cell proliferative capacities by interacting with EZH2 to epigenetically reduce CDKN1A expression (21). Here, UCA1 is linked to non-small cell lung carcinoma.