Moreover, lncRNA UCA1 is physically linked to the enhancer of zeste homolog 2 (EZH2), which inhibits p27Kip1 through histone methylation (H3K27me3) in p27Kip1 promoter, thus promoting tumorigenesis in nude mice in hepatocellular carcinoma (12). This evidence concerns the gene CDKN1B and hepatocellular carcinoma.