Anti-inflammatory therapies directed at reducing the levels of these cytokines may be associated with better clinical outcomes. Therefore, we conducted a retrospective study to determine the correlation of the trend of pro-inflammatory cytokines, including ferritin, C-reactive protein (CRP), interleukin 6 (IL-6), procalcitonin, and lactic acid with the overall outcome of patients with COVID-19. This evidence concerns the gene CRP and COVID-19.