When cells detect iron deficiency, they try to restore its availability by generating an increase in ROS production and a decrease in antioxidant mechanisms such as superoxide dismutase (SOD), glutathione (GSH), and ascorbic acid, promoting a state of inflammation pulmonary and systemic as well as oxidative imbalance with genotoxic consequences and cell damage [51]. This evidence concerns the gene SOD1 and Iron deficiency anemia.