SOD1 and chronic obstructive pulmonary disease: Supplementation with oligomeric proanthocyanidins [47], a nutraceutical product extracted from grape seeds, significantly improved the oxidative state of COPD patients, reducing the concentration of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD); this was possibly related to the antioxidant effects of polyphenols present in grape seeds; in addition, it managed to improve the lipid profile of the patients.