TNF and COVID-19: This has been discussed in previously published reviews7-12 and as well, several experimental studies suggest that cytokine storm correlated with direct tissue injury and lead to unfavourable prognosis of severe form of the COVID-19 disease.7 Briefly, particularly high levels of IL-6, IL-10, IL-2R and TNF-α have been reported in patients with severe form of the disease13,14 although other authors suggest that more cytokines, such IL-1β, IL-1RA, IL-8, IL-18 are included in the COVID-19 pathogenesis.7,13,14