VEGF up-regulation was observed in several viral infections and it has been investigated as a target for potential therapy development.20 In addition, Huanget al., report higher levels of VEGF in hospitalized COVID-19 patients.19 Tanacanet al., had investigated the cytokine profile in pregnant women with COVID-19 where their results indicated significantly higher values for IFN-g andIL-6, and lower values of IL-2, IL-10 and IL-17, especially in those where complications like miscarriage and preterm delivery was evidenced.21 This evidence concerns the gene IFNG and viral infectious disease.