This conclusion is consistent with the previous research results, suggesting that lidocaine and polymetamidine have a synergistic effect, which can inhibit the oxidative stress injury mediated by nNOS, iNOS, and p22phox, p91phox, and p47phox proteins, and then play a protective role in the process of intracranial aneurysm clipping. Here, NCF1 is linked to Dilatation of the cerebral artery.