This was shown again by administration of an EET agonist that increased PGC-1 α, which induced the HO-1 increase, improved mitochondrial function, and induced a change in the pericardial and epicardial adipocyte phenotype from white to beige; the improved insulin receptor phosphorylation improved insulin sensitivity and resulted in reversal of heart failure [27]. The gene discussed is HMOX1; the disease is heart failure.