INS and Obesity: Furthermore, epoxyeicosatrienoic acid (EET), a molecule that inhibits the inflammatory process, improves insulin sensitivity, and decreases NOV was shown to attenuate obesity-induced cardiomyopathy by down regulating NOV, increasing heme oxygenase-1 (HO-1) and Wnt signaling in both cardiac and pericardial fat [15, 27].