HIF1A and obesity due to melanocortin 4 receptor deficiency: Thymoquinone (TQ) is another molecule that comes from the Nigella sativa plant that has major anti-inflammatory properties; in combination with omega fish oils, they improved insulin sensitivity in obesity and promoted the browning of white fat, with upregulation of mitochondrial enzymes, HO-1 levels, and reduction of the inflammatory adipokine NOV, twist-related protein (TWIST2), and the adipocyte hypoxia inducible factor HIF-1α [29].