Furthermore, epoxyeicosatrienoic acid (EET), a molecule that inhibits the inflammatory process, improves insulin sensitivity, and decreases NOV was shown to attenuate obesity-induced cardiomyopathy by down regulating NOV, increasing heme oxygenase-1 (HO-1) and Wnt signaling in both cardiac and pericardial fat [15, 27]. This evidence concerns the gene HMOX1 and obesity due to melanocortin 4 receptor deficiency.