Then, to explore the molecular mechanisms involved in SOX6 and SOX12 in RCC, we performed function and pathway enrichment analyses between high- and low-expression groups; we found that SOX6 and SOX12 might regulate the ccRCC progression through several cancer-related signaling pathways, such as cytokine-cytokine receptor interaction, IL-17 signaling pathway, and PI3K-Akt signaling pathway. This evidence concerns the gene SOX12 and nonpapillary renal cell carcinoma.