The top 5 core targets (IL-6, VEGFA, TNF, AKT1, and MAPK1) in the PPI network were docked with the main active components (quercetin, kaempferol, beta-carotene, isorhamnetin, and beta-sitosterol) of TDXD in treating HF and the positive drug (captopril) for HF. The gene discussed is TNF; the disease is hydrops fetalis.