The results of this study found that TDXD can significantly reduce the expression of P-Akt and P-MAPK in the cardiac tissue of rats with HF, suggesting that the role of TDXD in improving cardiac function, inhibiting cardiomyocyte apoptosis, and reducing the level of inflammatory cytokines is related to the regulation of PI3K/Akt and MAPK signaling pathways. Here, AKT1 is linked to hydrops fetalis.