In the KEGG analysis, the host genes of circRNAs were also enriched in the cAMP, CREB, MAPK, PI3K-Akt, and HIF signaling pathways, which are associated with pathophysiological mechanisms, such as oxidative stress injury, mitochondrial injury, inflammation, apoptosis, and neuronal regeneration after stroke. This evidence concerns the gene CREB1 and stroke disorder.