In the KEGG analysis, the host genes of circRNAs were also enriched in the cAMP, CREB, MAPK, PI3K-Akt, and HIF signaling pathways, which are associated with pathophysiological mechanisms, such as oxidative stress injury, mitochondrial injury, inflammation, apoptosis, and neuronal regeneration after stroke. The gene discussed is CREB1; the disease is Stroke.