Intense oxidative stress stimulates the ROS scavenging mechanisms, and the marked downregulation of circ_Gucy1a2_7 and circ_Ryr2_36 by more than 4-fold after stroke may lead to the release of adsorbed miR-7a-5p and the consequent downregulation of Keap1 at the posttranscriptional level. Here, KEAP1 is linked to stroke disorder.