Fei et al., also reported 204 differentially expressed LncRNAs in male osteoporosis (Fei et al., 2020), while Yang et al., identified 46 differentially expressed LncRNAs between osteoarthritis and osteolysis following total hip arthroplasty, and reported potential roles of specific LncRNA-mRNA pairs in regulating CD8A, CD8B and osteoclastogenesis in these patients (Yang et al., 2021). The gene discussed is CD8A; the disease is osteoarthritis.