TGFBR3 expression is significantly upregulated in patients after myocardial infarction and may serve as a therapeutic target and biomarker for myocardial damage by activating p38 MAPK to induce cardiomyocyte apoptosis (Chu et al., 2011; Chen et al., 2019). The gene discussed is TGFBR3; the disease is myocardial infarction.