In total, 15 genes were detected to harbor MEs among the epilepsy-associated genes, and genes which are more frequent to harbor MEs in TLE include BRD2, DOCK7, HERC2, IGSF8, NF1, NIN, PCLO, RFX3, SCN1A, SCNM1, and TBCK (Supplementary Table S4). This evidence concerns the gene IGSF8 and epilepsy.