For epilepsy, limited studies have also implied a role of MEs via ME-mediated genomic rearrangements in CDKL5 and ALDH7A1 (Erez et al., 2009; Mefford et al., 2015) and de novo somatic L1 insertions biased toward epilepsy-associated genes (Doyle et al., 2021). Here, ALDH7A1 is linked to epilepsy.