EGFR and cancer: Understanding these genetic alterations may assist in interpreting the molecular mechanism of EGFR-MT LUAD, but the genetic and cytogenetic complexities intrinsic to EGFR-MT LUAD are difficult to uncover because cancer biology is regulated by several factors, including ferroptosis, hypoxia, and tumor microenvironment (Hanahan and Coussens, 2012; Qiu et al., 2017; Gao et al., 2019).