Some were further confirmed to be associated with BMD, for instance, serum calcium (Sun et al., 2021), sex hormone-binding globulin (Qu et al., 2021) and age at menarche (Magnus et al., 2020), while others such as vascular endothelial growth factor, uric acid and serum vitamin D got no evidence for their correlations with osteoporosis (Lee and Song, 2019; Sun et al., 2019; Keller-Baruch et al., 2020). The gene discussed is SHBG; the disease is osteoporosis.