MMP8 and postmenopausal osteoporosis: For example, Zuo et al. (Zuo et al., 2020) found that MMP-8 was involved in the 17β-Estradiol replacement therapy for postmenopausal osteoporosis, while Viljakainen et al. (Viljakainen et al., 2017) found that there was no significant correlation between MMP-8 levels and low BMD.