For the rare variants burden analysis, we did not find a significant enrichment of rare variants of CYLD in Chinese patients with ALS, which was consistent with the finding of the original study, which only detected a significant enrichment of rare variants in the deubiquitinase domain of CYLD (amino acids 593–948) in FTD patients, but not in ALS either in the whole gene level or the deubiquitinase domain (Dobson-stone et al., 2020). The gene discussed is CYLD; the disease is amyotrophic lateral sclerosis.