The previous study on the large ALS-FTD pedigree reported that one patient had clinical diagnosis of FTD-ALS, Paget’s disease, and parkinsonism (Dobson-stone et al., 2020), whose pathological findings met neuropathological criteria for both cortical basal degeneration (CBD) FTLD with tau pathology (CBD FTLD-tau) and FTLD with type B TDP-43 pathology (type B FTLD-TDP). This evidence concerns the gene MAPT and frontotemporal dementia.