CD163 and rheumatoid arthritis: To identify signature differences between the early RA and control groups, we developed a Partial Least Square Discriminant Analysis (PLS-DA) model using the following variables: exomiR-144-3p, exomiR-25-3p, exomiR-15a-5p, exomiR-451a, exomiR-107, exomiR-185-5p, sTWEAK and sCD163.