TLR2 and glioblastoma: Toll-like receptor 2 (TLR2), one of the HMBG1 receptors, has been considered to involve in the production of NETs, and HMGB1-mediated TLR2 signaling plays a critical role in eliciting glioblastoma regression, suggesting the prospect of NETs in malignant brain tumors (117–119).