T-cell immunoglobulin and mucin domain-3 (TIM-3) also has been proven to interact with HMBG1 in TADCs and then preventing the nucleic acids from localizing into the endosomal vesicles, thus playing a role in blowing the antitumor effect of tumor-associated dendritic cells (TADCs) (113–115). This evidence concerns the gene HAVCR2 and neoplasm.