In the context of the basic pathology with bone marrow failure or neutropenia—that is, the function of an affected gene being equally essential for some or all hematopoietic lineages—reversion mutations have been detected in cells other than lymphoid lineages, as observed in SAMD9/SAMD9L syndrome, MYSM1 deficiency, WHIM syndrome, GATA2 deficiency, and Fanconi anemia (94, 96, 98, 105, 106, 112) (Table 3 and Figure 2C). This evidence concerns the gene MYSM1 and Bone marrow hypocellularity.