BCL2 and B-cell non-Hodgkin lymphoma: Nevertheless, considering the role of BCL-2 family members in B-cell lymphoma therapy (56), it is not surprising that combinations of CAR T-cell therapy with compounds targeting apoptosis regulators, like BH3 mimetics (e.g., ABT-737) or pan-BCL-2 inhibitors, are currently discussed for mature B-cell malignancies.